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KMID : 0382619880080020823
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Hanyang Journal of Medicine
1988 Volume.8 No. 2 p.823 ~ p.838
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Effect of Taurine on Histamine-Induced Changes in the Action Potential of the Rabbit Sinus Node Cells
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Abstract
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Effects of taurine and histamine on the electrophysiological characteristics of the rabbit sinus node cells were investigated by a conventional microelectrode techni-que. Also studied was the effect of taurine on histamine-induced changes in the ac-tion potential of the pacemaker cells, as well as on histamine-induced arrhythmias.
When the sinus node cells were exposed to histamine the overshoot potential, con-sequently action potential was decreased, action potential duration was shortened and the rate of spontaneous firing increased markedly. Effect of histamine on the cellular . potential peaked between 5 to 10 minutes after superfusion of the cardiac pacemaker cells
On the other hand, taurine (0.01-0.5%) did not affect the transmembrane potential of the rabbit sinus node cells.
After pretreatment of the cardiac pacemaker cells with taurine, effect of histamine on the action potential amplitude was depressed prominently whereas action poten-tial duration was not altered by histamine.
Histamine-induced tachycardia or dysrhythmia were significantly supressed in 1-2 hours following superfusion of the sinus node cells with taurine solution.
The possible mechanism underlying antiarrhythmic action of taurine on histamine- induced arrhythmia was discussed.
It is concluded that taurine has a protective action against adverse effects of histamine on the cardiac pacemaker cells of the rabbit heart.
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